What is metabolism?
Metabolism is the term for the thousands of biochemical reactions involving transfers of matter and / or energy that take place mainly in the body’s cells. It is the process by which your body converts the food and water you consume into all the elements needed by your body and into the energy needed to power everything you do, from moving to thinking to growing. In many diseases, some of these metabolic processes are disturbed. By exploring these disturbed metabolic pathways, MedDay is able to identify new compounds or strategies to improve the function of the central nervous system in people with neurodegenerative disorders.
The Role of Metabolism in Health and Disease
Metabolism refers to the intricate network of chemical reactions that occur within the body, facilitating the conversion of food and water into essential molecules and energy. These reactions, driven by enzymes, are categorized into two main processes: catabolism, which breaks down molecules to release energy, and anabolism, which builds complex molecules necessary for cell repair and growth. Together, these processes maintain homeostasis, ensuring the body’s cells function optimally.
In healthy individuals, metabolic pathways are tightly regulated to meet the demands of various bodily functions, from muscle contraction and neural activity to hormone synthesis and waste removal. For example, glucose metabolism provides a primary energy source for the brain, accounting for approximately 20% of the body’s total energy expenditure, even at rest. Similarly, lipids and amino acids contribute to energy production and the synthesis of cellular structures.
However, disruptions in metabolic processes can lead to significant health challenges. Conditions such as diabetes, obesity, and thyroid disorders arise from imbalances in how energy is processed or stored. In neurodegenerative diseases like Alzheimer’s or Parkinson’s, researchers have observed abnormalities in the metabolism of glucose and lipids, which impair brain function and accelerate disease progression.
At MedDay, metabolic research is central to identifying potential treatments for neurodegenerative disorders. By studying specific metabolic disruptions, such as impaired energy production in brain cells, researchers aim to develop innovative therapies that restore balance and improve central nervous system function. These efforts involve exploring novel compounds that target malfunctioning metabolic pathways, offering hope for conditions where traditional treatments are limited.